Key features of inhibitor binding to the human mitochondrial pyruvate carrier hetero-dimer

Objective: The mitochondrial pyruvate carrier (MPC) has emerged as a promising drug target for metabolic disorders, including non-alcoholic steatohepatitis and diabetes, metabolically dependent cancers and neurodegenerative diseases. A range of structurally diverse small molecule inhibitors have bee...

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Detalhes bibliográficos

Principais autores:	Sotiria Tavoulari, Tom J.J. Schirris, Vasiliki Mavridou, Chancievan Thangaratnarajah, Martin S. King, Daniel T.D. Jones, Shujing Ding, Ian M. Fearnley, Edmund R.S. Kunji
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2022-06-01
coleção:	Molecular Metabolism
Assuntos:	Mitochondria Mitochondrial transport Mitochondrial pyruvate carrier Inhibition Small molecules
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2212877822000382
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