Capsid-mediated control of adeno-associated viral transcription determines host range

Summary: Adeno-associated virus (AAV) is a member of the genus Dependoparvovirus, which infects a wide range of vertebrate species. Here, we observe that, unlike most primate AAV isolates, avian AAV is transcriptionally silenced in human cells. By swapping the VP1 N terminus from primate AAVs (e.g.,...

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Bibliografiske detaljer

Principais autores:	Ezra J. Loeb, Patrick L. Havlik, Zachary C. Elmore, Alan Rosales, Sophia M. Fergione, Trevor J. Gonzalez, Timothy J. Smith, Abigail R. Benkert, David N. Fiflis, Aravind Asokan
Format:	Artigo
Sprog:	Inglês
Udgivet:	Elsevier 2024-03-01
Serier:	Cell Reports
Fag:	CP: Microbiology CP: Molecular biology
Online adgang:	http://www.sciencedirect.com/science/article/pii/S2211124724002304
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