Characterization of novel neutralizing mouse monoclonal antibody JM1-24-3 developed against MUC18 in metastatic melanoma

Abstract Background MUC18 is a glycoprotein highly expressed on the surface of melanoma and other cancers which promotes tumor progression and metastasis. However, its mechanism of action and suitability as a therapeutic target are unknown. Methods A monoclonal antibody (mAb) (JM1-24-3) was generate...

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Detalhes bibliográficos

Principais autores:	Runhua Feng, Yuling Wang, Vijaya Ramachandran, Qinhong Ma, Matthew M. May, Ming Li, Joe X. Zhou, Xiang Xu, Kejing Xu, Shenying Fang, Weiya Xia, Dawen Sui, Huey Liu, Xiaolian Gao, Victor Prieto, Stephen C. Blacklow, Mason Lu, Jeffrey E. Lee
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2020-12-01
Colecção:	Journal of Experimental & Clinical Cancer Research
Assuntos:	MUC18 CD146 Metastatic melanoma Therapeutic antibody Targeted therapy
Acesso em linha:	https://doi.org/10.1186/s13046-020-01722-8
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