PRMT5 inhibition promotes cross-species spermatogonia expansion and suppresses differentiation

Abstract Spermatogonial stem cells (SSCs) hold great promise for treating male infertility, but their clinical translation is impeded by the lack of optimal conditions to maintain their undifferentiated state in vitro. In this study, we focused on epigenetic regulators upregulated during differentia...

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Auteurs principaux:	Zhaokai Yao, Wen Wang, Kang Tang, Yuning Yang, Shaofang Ren, Yetian Weng, Linzi Ma, Dingyao Chen, Haoxu Gu, Jialin Wan, Zhaoting Liu, Yi Zheng, Chaohui Li, Fang Luo, Xiao-Yang Zhao, Yong Fan
Format:	Artigo
Langue:	Inglês
Publié:	SpringerOpen 2026-07-01
Collection:	Cell Regeneration
Sujets:	Spermatogonial stem cells PRMT5 EPZ015666 Male infertility Cross-species validation
Accès en ligne:	https://doi.org/10.1186/s13619-026-00293-x
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