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Emerging Non-Conventional Approaches in mRNA-LNP Formulation for Therapeutic Applications

Lipid nanoparticles (LNPs) have become the cornerstone of nucleic acid delivery platforms, particularly in RNA-based vaccines and therapeutics. However, the conventional methods of LNP production, which are primarily reliant on microfluidic mixing of aqueous and organic solvent phases, pose limitati...

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Principais autores: Yitian Zhang, Gabriel Linaje-Ferrel, Juan Manuel Rocha Angel, Oindrila Banik, Earu Banoth, Amine A. Kamen, Naresh Yandrapalli, Ayyappasamy Sudalaiyadum Perumal
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2026-04-01
Colecção:Pharmaceutics
Assuntos:
mRNA-LNP
encapsulation
non-conventional methods
microfluidics
hot homogenization
thin film hydration
Acesso em linha:https://www.mdpi.com/1999-4923/18/5/527
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