Integrating multi-omics and network toxicology to identify FIS1 as a key target of environmental pollutants in male infertility

BackgroundMale infertility (MI) impacts about one in seven couples globally, involving complex gene-environment interactions. Environmental pollutants may disrupt spermatogenesis via mitochondrial dysfunction, but key targets and mechanisms are unclear. Integrating multi-omics with computational tox...

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Principais autores:	Qi Yu, Xi Wei, Jiang Shi, Wei Li, Yili Zhao, Qingtao Yang, Jun Qiao, Fa Sun, Tao Li
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-03-01
Colecção:	Frontiers in Cell and Developmental Biology
Assuntos:	FIS1 male infertility mitochondrial dysfunction reverse network toxicology summary-data-based mendelian randomization analysis
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fcell.2026.1788805/full
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