Mechanisms of Substrate Recognition by the Multispecific Protein Lysine Methyltransferase SETD6

The SETD6 protein lysine methyltransferase monomethylates specific lysine residues in a diverse set of substrates which contain the target lysine residue in a highly variable amino acid sequence context. To investigate the mechanism underlying this multispecificity, we analyzed SETD6 substrate recog...

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Detalhes bibliográficos

Principais autores:	Gizem T. Ulu, Sara Weirich, Jana Kehl, Thyagarajan T. Chandrasekaran, Franziska Dorscht, Dan Levy, Albert Jeltsch
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2025-10-01
Colecção:	Life
Assuntos:	SETD6 protein lysine methylation protein lysine methyltransferase enzyme specificity enzyme–substrate interaction
Acesso em linha:	https://www.mdpi.com/2075-1729/15/10/1578
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