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APP-CD74 axis mediates endothelial cell-macrophage communication to promote kidney injury and fibrosis

BackgroundKidney injuries often carry a grim prognosis, marked by fibrosis development, renal function loss, and macrophage involvement. Despite extensive research on macrophage polarization and its effects on other cells, like fibroblasts, limited attention has been paid to the influence of non-imm...

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Principais autores: Bin Liu, Faping Li, Yuxiong Wang, Xin Gao, Yunkuo Li, Yishu Wang, Honglan Zhou
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2024-09-01
Serier:Frontiers in Pharmacology
Fag:
renal fibrosis
single-cell RNA sequencing
endothelial cell
macrophage
intercellular communication
Online adgang:https://www.frontiersin.org/articles/10.3389/fphar.2024.1437113/full
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