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ABCB1 and ABCG2 Overexpression Mediates Resistance to the Phosphatidylinositol 3-Kinase Inhibitor HS-173 in Cancer Cell Lines

Constitutive activation of the phosphoinositide-3-kinase (PI3K)/Akt signaling pathway is crucial for tumor growth and progression. As such, this pathway has been an enticing target for drug discovery. Although HS-173 is a potent PI3K inhibitor that halts cancer cell proliferation via G2/M cell cycle...

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Principais autores: Chung-Pu Wu, Cheng-Yu Hung, Ya-Ju Hsieh, Megumi Murakami, Yang-Hui Huang, Tsung-Yao Su, Tai-Ho Hung, Jau-Song Yu, Yu-Shan Wu, Suresh V. Ambudkar
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2023-03-01
Serier:Cells
Fag:
multidrug resistance
ABCB1
ABCG2
PI3K
HS-173
Online adgang:https://www.mdpi.com/2073-4409/12/7/1056
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