Muscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localization

The exact molecular mechanisms driving FUS-mediated toxicity remain unclear. Here, the authors demonstrate that muscleblind (Mbl) is a novel modifier of FUS-associated ALS, with knockdown of endogenous Mbl suppressing neuromuscular junction defects and motor dysfunctions associated with FUS expressi...

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Detalhes bibliográficos

Principais autores:	Ian Casci, Karthik Krishnamurthy, Sukhleen Kour, Vadreenath Tripathy, Nandini Ramesh, Eric N. Anderson, Lara Marrone, Rogan A. Grant, Stacie Oliver, Lauren Gochenaur, Krishani Patel, Jared Sterneckert, Amanda M. Gleixner, Christopher J. Donnelly, Marc-David Ruepp, Antonella M. Sini, Emanuela Zuccaro, Maria Pennuto, Piera Pasinelli, Udai Bhan Pandey
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2019-12-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-019-13383-z
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