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Molecular Basis for Ser/Thr Specificity in PKA Signaling

cAMP-dependent protein kinase (PKA) is the major receptor of the second messenger cAMP and a prototype for Ser/Thr-specific protein kinases. Although PKA strongly prefers serine over threonine substrates, little is known about the molecular basis of this substrate specificity. We employ classical en...

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Principais autores: Matthias J. Knape, Maximilian Wallbott, Nicole C. G. Burghardt, Daniela Bertinetti, Jan Hornung, Sven H. Schmidt, Robin Lorenz, Friedrich W. Herberg
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2020-06-01
Serier:Cells
Fag:
cAMP-dependent protein kinase
PKA
cAMP signaling
protein kinases
kinase function
phosphorylation
Online adgang:https://www.mdpi.com/2073-4409/9/6/1548
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