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IP3 mediated global Ca2+ signals arise through two temporally and spatially distinct modes of Ca2+ release

The ‘building-block’ model of inositol trisphosphate (IP3)-mediated Ca2+ liberation posits that cell-wide cytosolic Ca2+ signals arise through coordinated activation of localized Ca2+ puffs generated by stationary clusters of IP3 receptors (IP3Rs). Here, we revise this hypothesis, applying fluctuati...

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Bibliografiske detaljer
Principais autores: Jeffrey T Lock, Ian Parker
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2020-05-01
Serier:eLife
Fag:
Online adgang:https://elifesciences.org/articles/55008
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