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TET Upregulation Leads to 5-Hydroxymethylation Enrichment in Hepatoblastoma

Hepatoblastoma is an embryonal liver tumor carrying few genetic alterations. We previously disclosed in hepatoblastomas a genome-wide methylation dysfunction, characterized by hypermethylation at specific CpG islands, in addition to a low-level hypomethylation pattern in non-repetitive intergenic se...

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Autores principales: Maria Prates Rivas, Talita Ferreira Marques Aguiar, Gustavo Ribeiro Fernandes, Luiz Carlos Caires-Júnior, Ernesto Goulart, Kayque Alves Telles-Silva, Monica Cypriano, Silvia Regina Caminada de Toledo, Carla Rosenberg, Dirce Maria Carraro, Cecilia Maria Lima da Costa, Isabela Werneck da Cunha, Ana Cristina Victorino Krepischi
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2019-06-01
Colección:Frontiers in Genetics
Materias:
hepatoblastoma
epigenetics
hydroxymethylation
active demethylation
DNA hypomethylation
Acceso en línea:https://www.frontiersin.org/article/10.3389/fgene.2019.00553/full
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