Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism

Anti-resorptive bone therapies also inhibit bone formation, as osteoclasts secrete factors that stimulate bone formation by osteoblasts. Here, the authors identify osteoclast-secreted factors that couple bone resorption to bone formation in healthy subjects, and show that osteoclast-derived DPP4 may...

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Hlavní autoři:	Megan M. Weivoda, Chee Kian Chew, David G. Monroe, Joshua N. Farr, Elizabeth J. Atkinson, Jennifer R. Geske, Brittany Eckhardt, Brianne Thicke, Ming Ruan, Amanda J. Tweed, Louise K. McCready, Robert A. Rizza, Aleksey Matveyenko, Moustapha Kassem, Thomas Levin Andersen, Adrian Vella, Matthew T. Drake, Bart L. Clarke, Merry Jo Oursler, Sundeep Khosla
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2020-01-01
Edice:	Nature Communications
On-line přístup:	https://doi.org/10.1038/s41467-019-14003-6
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