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Trans-Ned 19-Mediated Antagonism of Nicotinic Acid Adenine Nucleotide—Mediated Calcium Signaling Regulates Th17 Cell Plasticity in Mice

Nicotinic acid adenine dinucleotide phosphate (NAADP) is the most potent Ca<sup>2+</sup> mobilizing agent and its inhibition proved to inhibit T-cell activation. However, the impact of the NAADP signaling on CD4<sup>+</sup> T-cell differentiation and plasticity and on the inflammation in tissues oth...

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Principais autores: Mikołaj Nawrocki, Niels Lory, Tanja Bedke, Friederike Stumme, Björn-Phillip Diercks, Andreas H. Guse, Chris Meier, Nicola Gagliani, Hans-Willi Mittrücker, Samuel Huber
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2021-11-01
coleção:Cells
Assuntos:
adenine nucleotides
NAADP
Ca<sup>2+</sup> signaling
T cells
immune regulation
inflammatory diseases
Acesso em linha:https://www.mdpi.com/2073-4409/10/11/3039
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