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Piperlongumine Inhibits Thioredoxin Reductase 1 by Targeting Selenocysteine Residues and Sensitizes Cancer Cells to Erastin

Piperlongumine, a natural alkaloid substance extracted from the fruit of the long pepper (<i>Piper longum Linn</i>.), is known to inhibit the cytosolic thioredoxin reductase (TXNRD1 or TrxR1) and selectively kill cancer cells. However, the details and mechanism of the inhibition by piperlongumine ag...

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Principais autores: Yijia Yang, Shibo Sun, Weiping Xu, Yue Zhang, Rui Yang, Kun Ma, Jie Zhang, Jianqiang Xu
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2022-04-01
Serier:Antioxidants
Fag:
piperlongumine
thioredoxin reductase 1
erastin
glutathione
selenocysteine
CB-839
Online adgang:https://www.mdpi.com/2076-3921/11/4/710
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