Tyrosine Phosphorylation of Botulinum Neurotoxin Protease Domains
Botulinum neurotoxins are most potent of all toxins. Their N-terminal light chain domain (Lc) translocates into peripheral cholinergic neurons to exert its endoproteolytic action leading to muscle paralysis. Therapeutic development against these toxins is a major challenge due to their in vitro and...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Frontiers Media S.A.
2012-06-01
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| Schriftenreihe: | Frontiers in Pharmacology |
| Schlagworte: | |
| Online-Zugang: | http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00102/full |
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