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Application of single cell multiomics points to changes in chromatin accessibility near calcitonin receptor like receptor and a possible role for adrenomedullin in the post-shock lung

IntroductionAcute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a commonly occurring sequelae of traumatic injury resulting from indirect insults like hypovolemic shock and/or extrapulmonary sepsis. The high lethality rate associated with these pathologies outlines the importance o...

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Principais autores: Brandon E. Armstead, Chung Sunny Lee, Yaping Chen, Runping Zhao, Chun-Shiang Chung, Alger M. Fredericks, Sean F. Monaghan, Alfred Ayala
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2023-04-01
Serier:Frontiers in Medicine
Fag:
shock
sepsis
trauma
single cell
multiomics
ALI
Online adgang:https://www.frontiersin.org/articles/10.3389/fmed.2023.1003121/full
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