Protective efficacy of cross-reactive CD8+ T cells recognising mutant viral epitopes depends on peptide-MHC-I structural interactions and T cell activation threshold.

Emergence of a new influenza strain leads to a rapid global spread of the virus due to minimal antibody immunity. Pre-existing CD8(+) T-cell immunity directed towards conserved internal viral regions can greatly ameliorate the disease. However, mutational escape within the T cell epitopes is a subst...

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Principais autores:	Sophie A Valkenburg, Stephanie Gras, Carole Guillonneau, Nicole L La Gruta, Paul G Thomas, Anthony W Purcell, Jamie Rossjohn, Peter C Doherty, Stephen J Turner, Katherine Kedzierska
Format:	Artigo
Jezik:	Inglês
Izdano:	Public Library of Science (PLoS) 2010-08-01
Serija:	PLoS Pathogens
Online dostop:	https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20711359/pdf/?tool=EBI
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