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Epigenetic DNA Modifications Upregulate SPRY2 in Human Colorectal Cancers

Conventional wisdom is that Sprouty2 (SPRY2), a suppressor of Receptor Tyrosine Kinase (RTK) signaling, functions as a tumor suppressor and is downregulated in many solid tumors. We reported, for the first time, that increased expression of SPRY2 augments cancer phenotype and Epithelial-Mesenchymal-...

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Principais autores: Alexei J. Stuckel, Shuai Zeng, Zhen Lyu, Wei Zhang, Xu Zhang, Urszula Dougherty, Reba Mustafi, Qiong Zhang, Trupti Joshi, Marc Bissonnette, Samrat Roy Choudhury, Sharad Khare
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2021-10-01
coleção:Cells
Assuntos:
colorectal cancer
DNA methylation
epigenetic regulation
SPRY2 gene expression
5-hydroxymethylcytosine
CTCF transcription factor
Acesso em linha:https://www.mdpi.com/2073-4409/10/10/2632
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