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Human umbilical cord-derived mesenchymal stem cells ameliorate insulin resistance by suppressing NLRP3 inflammasome-mediated inflammation in type 2 diabetes rats

Abstract Background Insulin resistance is one of the most common and important pathological features of type 2 diabetes (T2D). Recently, insulin resistance is increasingly considered to be associated with systemic chronic inflammation. Elevated levels of tumor necrosis factor (TNF)-α and interleukin...

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Principais autores: Xiaoya Sun, Haojie Hao, Qingwang Han, Xiaoyan Song, Jiejie Liu, Liang Dong, Weidong Han, Yiming Mu
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2017-11-01
Series:Stem Cell Research & Therapy
Assuntos:
Mesenchymal stem cells
Inflammation
Insulin resistance
NLRP3 inflammasome
Palmitic acid
Lipopolysaccharide
Acceso en liña:http://link.springer.com/article/10.1186/s13287-017-0668-1
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