Claudin-2 enhances human antibody-mediated complement-dependent cytotoxicity of porcine endothelial cells by modulating antibody binding and complement activation

BackgroundImmune rejection represents a significant barrier to transplantation, especially in the context of xenotransplantation. Endothelial cells (ECs) derived from pigs serve as the initial barrier against the human immune system in xenotransplantation. Tight junction proteins are essential compo...

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Autors principals:	Weilong Li, Fang Yang, Dexin Yang, Zhuoheng Song, Zigan Xu, Jinmei Wu, Yanmei Li, Zixi Chen, Peishan Chen, Yeye Yu, Ting Xie, Cuishan Yang, Liying Zhou, Shaodong Luan, Hanchao Gao
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2025-02-01
Col·lecció:	Frontiers in Immunology
Matèries:	xenotransplantation immune rejection Claudin-2 PIECs PAECs complement
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1547512/full
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