Identification and preclinical efficacy evaluation of two lytic bacteriophages targeting highly virulent and multidrug-resistant Klebsiella pneumoniae

Abstract Background The emergence of MDR K. pneumoniae poses a critical challenge in treating respiratory-associated pneumonia. Bacteriophages are promising antibiotic alternatives with unique features. This study aimed to isolate new bacteriophages from the hospital environment and investigate thei...

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Hauptverfasser:	Ai Guo, Dianbao Zuo, Li Shi, Ming Guo, Jinquan Li, Caili Li, Puqing Wang, Xiaodong Sun, Ming Sang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2025-08-01
Schriftenreihe:	Annals of Clinical Microbiology and Antimicrobials
Schlagworte:	Lytic bacteriophage Multidrug-resistant Klebsiella pneumoniae Bacteriophage therapy Biofilm degradation Histopathology
Online-Zugang:	https://doi.org/10.1186/s12941-025-00812-9
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