Brucella spp. Omp25 Promotes Proteasome-Mediated cGAS Degradation to Attenuate IFN-β Production

Type I interferons (IFN), a family of cytokines widely expressed in various tissues, play important roles in anti-infection immunity. Nevertheless, it is not known whether Brucella spp. could interfere with IFN-I production induced by other pathogens. This study investigated the regulatory roles of...

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Bibliografiske detaljer

Principais autores:	Ruizhen Li, Wenli Liu, Xiangrui Yin, Fangfang Zheng, Zhenyu Wang, Xingchen Wu, Xiaohua Zhang, Qian Du, Yong Huang, Dewen Tong
Format:	Artigo
Sprog:	Inglês
Udgivet:	Frontiers Media S.A. 2021-07-01
Serier:	Frontiers in Microbiology
Fag:	Brucella spp. Omp25 macrophage cyclic guanosine monophosphate–adenosine monophosphate synthase interferon β
Online adgang:	https://www.frontiersin.org/articles/10.3389/fmicb.2021.702881/full
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