Irisin Increases Sirtuin 1 to Improve Glucocorticoid-Induced Sarcopenia and Mitochondrial Dysfunction

Sarcopenia, characterized by progressive skeletal muscle mass, strength, and functional loss, imposes a substantial global health burden. Irisin, a myokine derived from fibronectin type III domain-containing protein 5 (FNDC5), is critical for muscle health. Here, we investigate its role in mitigatin...

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Hauptverfasser: Hongwei Shi, Wen Sun, Xiaoyuan Cao, Xuepeng Fan, Wenjuan Xie, Xiaojing Hao, Simiao Wang, Jiayin Lu, Yi Yan, Xiaomao Luo, Yanjun Dong, Haidong Wang, Juan Wang
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2025-10-01
Schriftenreihe:Cells
Schlagworte:
irisin
sirtuin 1
glucocorticoids
muscle atrophy
mitochondrial dysfunction
Online Zugang:https://www.mdpi.com/2073-4409/14/21/1675
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