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Brain Oxygen Extraction and Metabolism in Pediatric Patients With Sickle Cell Disease: Comparison of Four Calibration Models

Sickle cell disease (SCD) is an inherited hemoglobinopathy with an increased risk of neurological complications. Due to anemia and other factors related to the underlying hemoglobinopathy, cerebral blood flow (CBF) increases as compensation; however, the nature of alterations in oxygen extraction fr...

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Main Authors: Zixuan Lin, Tiffany McIntyre, Dengrong Jiang, Alicia Cannon, Peiying Liu, Aylin Tekes, James F. Casella, Keith Slifer, Hanzhang Lu, Eboni Lance
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Physiology
Subjects:
sickle cell disease
OEF
CMRO2
CBF
TRUST MRI
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.814979/full
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