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Preclinical Assessment of Atorvastatin for Treatment of Endocardial Fibroelastosis

Summary: Endocardial fibroelastosis is a condition caused by the fibrogenic activation of endothelial cells via endothelial-to-mesenchymal transition of the endocardium, which is regulated by the transforming growth factor-β pathway. Atorvastatin, a statin, can protect the vascular endothelium by up...

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Principais autores: Daniel Diaz-Gil, MD, Gregor Gierlinger, MD, Natalia Silva-Gomez, Cand Med, Lavinia Rech, MD, PhD, Jesus Ortiz-Urbina, MD, Kerstin Saraci, Cand Med, Sophia Koutsogiannaki, PhD, Cordula M. Wolf, MD, Rainer G. Kozlik-Feldmann, MD, Rudolf Mair, MD, Juan M. Melero-Martin, PhD, Sitaram M. Emani, MD, Guillermo García-Cardeña, PhD, Pedro J. del Nido, MD, Ingeborg Friehs, MD
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2025-09-01
coleção:JACC: Basic to Translational Science
Assuntos:
atorvastatin
congenital heart disease
endocardial fibroelastosis
endothelial-mesenchymal transition
hypoplastic left heart syndrome
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2452302X25001664
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