Hypoxia-inducible factor 1 protects neurons from Sarm1-mediated neurodegeneration
Summary: The sterile alpha and TIR motif-containing 1 (Sarm1) NAD+ hydrolase drives neurodegeneration, but how Sarm1 activity is regulated remains poorly defined. Using CRISPR-Cas9 screening, we found that loss of Vhl suppressed Sarm1-mediated cellular degeneration. Vhl promotes O2-dependent constit...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
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Elsevier
2026-02-01
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| Schriftenreihe: | Cell Reports |
| Schlagworte: | |
| Online-Zugang: | http://www.sciencedirect.com/science/article/pii/S2211124725016456 |
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