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Dimerization of kringle 1 domain from hepatocyte growth factor/scatter factor provides a potent MET receptor agonist

We designed and characterized a potent full MET receptor agonist consisting of two recombinantly linked HGF/SF kringle 1 domains and demonstrated its potential in epithelial tissue regeneration. Hepatocyte growth factor/scatter factor (HGF/SF) and its cognate receptor MET play several essential role...

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Principais autores: Giovanni de Nola, Bérénice Leclercq, Alexandra Mougel, Solenne Taront, Claire Simonneau, Federico Forneris, Eric Adriaenssens, Hervé Drobecq, Luisa Iamele, Laurent Dubuquoy, Oleg Melnyk, Ermanno Gherardi, Hugo de Jonge, Jérôme Vicogne
Formato: Artigo
Idioma:Inglês
Publicado em: Life Science Alliance LLC 2022-12-01
coleção:Life Science Alliance
Acesso em linha:https://www.life-science-alliance.org/lookup/doi/10.26508/lsa.202201424
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