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Pan-Cancer Analysis Reveals Disrupted Circadian Clock Associates With T Cell Exhaustion

Although dysfunctional circadian clock has emerged as a hallmark of cancer, fundamental gaps remain in our understanding of the underlying mechanisms involved. Here, we systematically analyze the core genes of the circadian clock (CLOCK, ARNTL, ARNTL2, NPAS2, NR1D1, NR1D2, CRY1, CRY2, RORA, RORB, RO...

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Principais autores: Yingcheng Wu, Baorui Tao, Tianyang Zhang, Yihui Fan, Renfang Mao
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Immunology
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Acceso en liña:https://www.frontiersin.org/article/10.3389/fimmu.2019.02451/full
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