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Regulation of BMP4/Dpp retrotranslocation and signaling by deglycosylation

During endoplasmic reticulum-associated degradation (ERAD), the cytoplasmic enzyme N-glycanase 1 (NGLY1) is proposed to remove N-glycans from misfolded N-glycoproteins after their retrotranslocation from the ER to the cytosol. We previously reported that NGLY1 regulates Drosophila BMP signaling in a...

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Autores principales: Antonio Galeone, Joshua M Adams, Shinya Matsuda, Maximiliano F Presa, Ashutosh Pandey, Seung Yeop Han, Yuriko Tachida, Hiroto Hirayama, Thomas Vaccari, Tadashi Suzuki, Cathleen M Lutz, Markus Affolter, Aamir Zuberi, Hamed Jafar-Nejad
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications Ltd 2020-07-01
Colección:eLife
Materias:
ERAD
N-glycosylation
deglycosylation
BMP signaling
retrotranslocation
NGLY1
Acceso en línea:https://elifesciences.org/articles/55596
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