BKI-1748 confers a high level of protection against ovine congenital toxoplasmosis when administered after IgM seroconversion

BackgroundUnlike mouse models of congenital toxoplasmosis, pregnant sheep models provide the opportunity to evaluate treatment strategies that more closely resemble clinical practice in pregnant women, including chemotherapeutic interventions initiated after specific IgM seroconversion. BKI-1748, wh...

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Autori principali:	Roberto Sánchez-Sánchez, Natalia Velasco-Jiménez, David Arranz-Solís, Miguel Criado, Ignacio Ferre, Michela Re, Matthew A. Hulverson, Ryan Choi, Lynn K. Barrett, Andrew Hemphill, Wesley C. Van Voorhis, Luis Miguel Ortega-Mora
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2026-04-01
Serie:	Frontiers in Cellular and Infection Microbiology
Soggetti:	BKI-1748 congenital toxoplasmosis efficacy IgM sheep Toxoplasma gondii
Accesso online:	https://www.frontiersin.org/articles/10.3389/fcimb.2026.1819490/full
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