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T-bet Expression in Peripheral Th17.0 Cells Is Associated With Pulmonary Function Changes in Sarcoidosis

Background: Interferon-gamma (IFN-γ) is a key mediator of sarcoidosis-related granulomatous inflammation. Previous findings of IFN-γ-producing Th17 cells in bronchoalveolar lavage fluid from sarcoidosis patients invokes the transition of Th17.0 cells to Th17.1 cells in the disease's pathogenesis. Si...

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Principais autores: Nicholas K. Arger, Siddharth Machiraju, Isabel E. Allen, Prescott G. Woodruff, Laura L. Koth
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020-07-01
Serier:Frontiers in Immunology
Fag:
sarcoidosis
Th17
Th17.1
Th1
T-bet
RORγt
Online adgang:https://www.frontiersin.org/article/10.3389/fimmu.2020.01129/full
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