Dysfunctional mitochondria uphold calpain activation: Contribution to Parkinson's disease pathology

Calpain is a ubiquitous calcium-sensitive protease that is essential for normal physiologic neuronal function. However, mitochondrial-mediated-calcium homeostasis alterations may lead to its pathologic activation that jeopardizes neuronal structure and function. Here, we provide evidence to support...

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Autores principales:	A. Raquel Esteves, Daniela M. Arduíno, Russell H. Swerdlow, Catarina R. Oliveira, Sandra M. Cardoso
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2010-03-01
Colección:	Neurobiology of Disease
Materias:	Calpain activation Alpha-synuclein oligomers Mitochondrial dysfunction Cybrids Parkinson's disease Alpha-synuclein aggregation
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S0969996109003660
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