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Integrative multi-omics analysis reveals IFIT3⁺ macrophage-associated ISG20 as a prognostic biomarker and elucidates underlying tumor-suppressive mechanisms in ovarian cancer

Abstract Ovarian cancer (OC) remains the most lethal gynecologic malignancy, with the regulatory role of innate immunity in its progression and treatment poorly understood. This study provides a thorough characterization of OC immune microenvironment by combining multi-omics data. Our findings show...

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Glavni autori: Xiushen Li, Wenhao Wu, Sailing Lin, Xiangyu Yang, Huimin Wang, Xiaoyong Chen, Liqin Bao, Qiongfang Fang, Qi Zhang, Jingxin Ma, Lijun Fan, Guli Zhu, Ruiqi Wang, Xiran Wang, Zhaorui Cheng, Weizheng Liang, Xueqing Wu
Format: Artigo
Jezik:Inglês
Izdano: BMC 2026-01-01
Serija:Journal of Ovarian Research
Teme:
Ovarian cancer
Innate immunity
Multi-Omics
Tumor microenvironment
Macrophage
Immunotherapy
Online pristup:https://doi.org/10.1186/s13048-025-01947-1
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