Physiologically based modeling of LNP-mediated delivery of mRNA in the vascular system
RNA therapeutics are an emerging, powerful class of drugs with potential applications in a wide range of disorders. A central challenge in their development is the lack of clear pharmacokinetic (PK)-pharmacodynamic relationship, in part due to the significant delay between the kinetics of RNA delive...
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| Автори: | , , , , , , , , , , , , |
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| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
Elsevier
2024-06-01
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| Серія: | Molecular Therapy: Nucleic Acids |
| Предмети: | |
| Онлайн доступ: | http://www.sciencedirect.com/science/article/pii/S2162253124000623 |
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