Sortilin participates in light-dependent photoreceptor degeneration in vivo.

Both proNGF and the neurotrophin receptor p75 (p75(NTR)) are known to regulate photoreceptor cell death caused by exposure of albino mice to intense illumination. ProNGF-induced apoptosis requires the participation of sortilin as a necessary p75(NTR) co-receptor, suggesting that sortilin may partici...

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Bibliografiske detaljer

Principais autores:	Ana M Santos, Noelia López-Sánchez, David Martín-Oliva, Pedro de la Villa, Miguel A Cuadros, José M Frade
Format:	Artigo
Sprog:	Inglês
Udgivet:	Public Library of Science (PLoS) 2012-01-01
Serier:	PLoS ONE
Online adgang:	https://doi.org/10.1371/journal.pone.0036243
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