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PRagMatic Pediatric Trial of Balanced vs nOrmaL Saline FlUid in Sepsis: study protocol for the PRoMPT BOLUS randomized interventional trial

Abstract Background/aims Despite evidence that preferential use of balanced/buffered fluids may improve outcomes compared with chloride-rich 0.9% saline, saline remains the most commonly used fluid for children with septic shock. We aim to determine if resuscitation with balanced/buffered fluids as...

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Tallennettuna:
Päätekijät: Scott L. Weiss, Fran Balamuth, Elliot Long, Graham C. Thompson, Katie L. Hayes, Hannah Katcoff, Marlena Cook, Elena Tsemberis, Christopher P. Hickey, Amanda Williams, Sarah Williamson-Urquhart, Meredith L. Borland, Stuart R. Dalziel, Ben Gelbart, Stephen B. Freedman, Franz E. Babl, Jing Huang, Nathan Kuppermann, for the Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis (PRoMPT BOLUS) Investigators of the PECARN, PERC, and PREDICT Networks
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BMC 2021-11-01
Sarja:Trials
Aiheet:
Sepsis
Septic shock
Pediatric
Intravenous fluid
Crystalloid
Saline
Linkit:https://doi.org/10.1186/s13063-021-05717-4
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