Targeted demethylation of the CDO1 promoter based on CRISPR system inhibits the malignant potential of breast cancer cells

Abstract Background Cysteine dioxygenase 1 (CDO1) is frequently methylated, and its expression is decreased in many human cancers including breast cancer (BC). However, the functional and mechanistic aspects of CDO1 inactivation in BC are poorly understood, and the diagnostic significance of serum C...

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Detalles Bibliográficos

Principais autores:	Jiaojiao Yang, Liyue Sun, Xiao‐Yun Liu, Chan Huang, Junling Peng, Xinxin Zeng, Hailin Zheng, Wenjian Cen, Yu‐Xia Xu, Weijie Zhu, Xiao‐Yan Wu, Dongyi Ling, Lu‐Lu Zhang, Mingbiao Wei, Ye Liu, Deshen Wang, Feng‐Hua Wang, Yu‐Hong Li, Qin Li, Ziming Du
Formato:	Artigo
Idioma:	Inglês
Publicado:	Wiley 2023-09-01
Series:	Clinical and Translational Medicine
Assuntos:	Breast cancer CDO1 epigenetic editing serum methylation biomarker targeted demethylation system
Acceso en liña:	https://doi.org/10.1002/ctm2.1423
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