Safety, immunogenicity, and protective efficacy of the intranasal live pertussis vaccine GamLPV in an infant monkey model (<i>Papio hamadryas</i>)

INTRODUCTION. The current progressive increase in pertussis incidence and infant mortality rates is due to the insufficient effectiveness of existing vaccines, both in Russia and worldwide. Previous clinical trials showed that healthy adult volunteers developed long-term antibacterial immunity after...

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Principais autores:	D. T. Kubrava, A. Yu. Medkova, A. Z. Matua, I. G. Kondzariya, A. A. Amichba, Kh. Z. Trapsh, L. V. Gamgiya, S. G. Kulikov, L. N. Sinyashina, Z. Ya. Mikvabiya, G. I. Karataev
Formato:	Artigo
Idioma:	Russo
Publicado em:	Ministry of Health of the Russian Federation. Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» 2024-12-01
coleção:	Биопрепараты: Профилактика, диагностика, лечение
Assuntos:	pertussis live pertussis vaccine intranasal administration monkeys hamadryas baboons papio hamadryas experimental model immunogenicity safety protective efficacy
Acesso em linha:	https://www.biopreparations.ru/jour/article/view/596
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