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A validated LC-MS/MS method for cellular thyroid hormone metabolism: Uptake and turnover of mono-iodinated thyroid hormone metabolites by PCCL3 thyrocytes.

Tyrosine and phenolic ring de-iodination of thyroid hormones (TH) is crucial for regulating their physiological activity. Furthermore, reactions such as de-carboxylation to thyronamines (TAM) and de-amination to thyroacetic acids (TAc) produce TH metabolites (THM) with distinct biological properties...

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Detalhes bibliográficos
Principais autores: Keith H Richards, Nancy Schanze, Ray Monk, Eddy Rijntjes, Daniel Rathmann, Josef Köhrle
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2017-01-01
coleção:PLoS ONE
Acesso em linha:http://europepmc.org/articles/PMC5570372?pdf=render
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