Epigenetic regulation of CD38/CD48 by KDM6A mediates NK cell response in multiple myeloma
Abstract Anti-CD38 monoclonal antibodies like Daratumumab (Dara) are effective in multiple myeloma (MM); however, drug resistance ultimately occurs and the mechanisms behind this are poorly understood. Here, we identify, via two in vitro genome-wide CRISPR screens probing Daratumumab resistance, KDM...
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| Principais autores: | , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Portfolio
2024-02-01
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| coleção: | Nature Communications |
| Acesso em linha: | https://doi.org/10.1038/s41467-024-45561-z |
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