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GLO1 cg26053840 Methylation Associates with Kidney Injury and Inflammatory Markers in Hospitalized Older Adults

The glyoxalase pathway detoxifies reactive dicarbonyls generated during hyperglycemia, but the role of its epigenetic regulation in renal dysfunction and inflammatory dysregulation in older adults remains unclear. We investigated CpG-specific DNA methylation within the glyoxal detoxification pathway...

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Principais autores: Carlo Fortunato, Francesco Piacenza, Gretta Veronica Badillo Pazmay, Marco Malavolta, Maurizio Cardelli, Antonio Cherubini, Leonardo Biscetti, Giuseppe Pelliccioni, Luca Soraci, Davide Gentilini, Luciano Calzari, Francesca Marchegiani, Rina Recchioni, Chiara Giordani, Giulia Matacchione, Matilde Sbriscia, Sonia Fantone, Roberta Galeazzi, Fabrizia Lattanzio, Anna Rita Bonfigli, Mirko Di Rosa, Fabiola Olivieri, Robertina Giacconi
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2026-05-01
Serier:Life
Fag:
GLO1
methylglyoxal
DNA methylation
hyperglycemia
inflammation
kidney dysfunction
Online adgang:https://www.mdpi.com/2075-1729/16/6/917
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