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Melatonin inhibits the caspase-1/cytochrome c/caspase-3 cell death pathway, inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis

Caspase-mediated cell death contributes to the pathogenesis of motor neuron degeneration in the mutant SOD1G93A transgenic mouse model of amyotrophic lateral sclerosis (ALS), along with other factors such as inflammation and oxidative damage. By screening a drug library, we found that melatonin, a p...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: Yi Zhang, Anna Cook, Jinho Kim, Sergei V. Baranov, Jiying Jiang, Karen Smith, Kerry Cormier, Erik Bennett, Robert P. Browser, Arthur L. Day, Diane L. Carlisle, Robert J. Ferrante, Xin Wang, Robert M. Friedlander
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Elsevier 2013-07-01
Rangatū:Neurobiology of Disease
Ngā marau:
Melatonin
Caspases
Cytochrome c
Apoptosis
Melatonin receptor 1A
Amyotrophic lateral sclerosis
Urunga tuihono:http://www.sciencedirect.com/science/article/pii/S096999611300096X
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