WWOX and Its Binding Proteins in Neurodegeneration
WW domain-containing oxidoreductase (WWOX) is known as one of the risk factors for Alzheimer’s disease (AD), a neurodegenerative disease. WWOX binds Tau via its C-terminal SDR domain and interacts with Tau phosphorylating enzymes ERK, JNK, and GSK-3β, and thereby limits AD progression. Loss of WWOX...
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| Principais autores: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI AG
2021-07-01
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| coleção: | Cells |
| Assuntos: | |
| Acesso em linha: | https://www.mdpi.com/2073-4409/10/7/1781 |
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