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Design, structure and plasma binding of ancestral β-CoV scaffold antigens

Abstract We report the application of ancestral sequence reconstruction on coronavirus spike protein, resulting in stable and highly soluble ancestral scaffold antigens (AnSAs). The AnSAs interact with plasma of patients recovered from COVID-19 but do not bind to the human angiotensin-converting enz...

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Autori principali: David Hueting, Karen Schriever, Rui Sun, Stelios Vlachiotis, Fanglei Zuo, Likun Du, Helena Persson, Camilla Hofström, Mats Ohlin, Karin Walldén, Marcus Buggert, Lennart Hammarström, Harold Marcotte, Qiang Pan-Hammarström, Juni Andréll, Per-Olof Syrén
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Portfolio 2023-10-01
Serie:Nature Communications
Accesso online:https://doi.org/10.1038/s41467-023-42200-x
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