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Subtype-Specific Ligand Binding and Activation Gating in Homomeric and Heteromeric P2X Receptors

P2X receptors are ATP-activated, non-specific cation channels involved in sensory signalling, inflammation, and certain forms of pain. Investigations of agonist binding and activation are essential for comprehending the fundamental mechanisms of receptor function. This encompasses the ligand recogni...

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Principais autores: Xenia Brünings, Ralf Schmauder, Ralf Mrowka, Klaus Benndorf, Christian Sattler
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2024-08-01
coleção:Biomolecules
Assuntos:
P2X receptors
fluorescent ATP
patch-clamp
ligand binding
membrane proteins
Mg<sup>2+</sup> modulation
Acesso em linha:https://www.mdpi.com/2218-273X/14/8/942
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