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STING agonists reduce genital chlamydial infection and attenuate inflammation and pathology

ABSTRACT The cGAS-STING pathway is activated during chlamydial infection and plays a critical role in controlling Chlamydia trachomatis infection in the mouse lower genital tract. The current study evaluated whether intravaginal administration of exogenous STING agonists could inhibit chlamydial inf...

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Main Authors: Xuemei Wang, Cuixiu Wu, Yidan Gao, Lijuan Jiang, Yuanshuo Guo, Na Cui, Qian Wang, Haoneng Tang, Shuping Hou, Chunfu Yang, Lingli Tang
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2026-06-01
Series:Infection and Immunity
Subjects:
STING agonist
Chlamydia
genital infection
2’3’-cGAMP
diABZI
Online Access:https://journals.asm.org/doi/10.1128/iai.00761-25
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