Megakaryocytic IGF1 coordinates activation and ferroptosis to safeguard hematopoietic stem cell regeneration after radiation injury

Abstract Background Hematopoietic stem cell (HSC) regeneration underlies hematopoietic recovery from myelosuppression, which is a life-threatening side effect of cytotoxicity. HSC niche is profoundly disrupted after myelosuppressive injury, while if and how the niche is reshaped and regulates HSC re...

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Auteurs principaux:	Weinian Liao, Xinliang Chen, Shuzhen Zhang, Jun Chen, Chaonan Liu, Kuan Yu, Yimin Zhang, Mo Chen, Fang Chen, Mingqiang Shen, Binghui Lu, Songling Han, Song Wang, Junping Wang, Changhong Du
Format:	Artigo
Langue:	Inglês
Publié:	BMC 2024-05-01
Collection:	Cell Communication and Signaling
Sujets:	Hematopoietic stem cell Megakaryocyte IGF1 Ferroptosis Ionizing radiation Myelosuppression
Accès en ligne:	https://doi.org/10.1186/s12964-024-01651-5
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