Characterization of pharmacogenomic variants in a Brazilian admixed cohort of elderly individuals based on whole-genome sequencing data

Introduction: Research in the field of pharmacogenomics (PGx) aims to identify genetic variants that modulate response to drugs, through alterations in their pharmacokinetics (PK) or pharmacodynamics (PD). The distribution of PGx variants differs considerably among populations, and whole-genome sequ...

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Principais autores:	Luciana Bertholim-Nasciben, Marilia O. Scliar, Guilherme Debortoli, Bhooma Thiruvahindrapuram, Stephen W. Scherer, Yeda A. O. Duarte, Mayana Zatz, Guilherme Suarez-Kurtz, Esteban J. Parra, Michel S. Naslavsky
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2023-05-01
coleção:	Frontiers in Pharmacology
Assuntos:	pharmacogenomics admixture population cohort whole-genome sequencing PharmGKB CPIC guidelines
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fphar.2023.1178715/full
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